Prostacyclin Mitigates Renal Fibrosis by Activating Fibroblast Prostaglandin I2 Receptor.
Jing LiYi GuanYunyu XuYingxue CaoQionghong XieRaymond C HarrisMatthew D BreyerLimin LuChuan Ming HaoPublished in: Journal of the American Society of Nephrology : JASN (2023)
PGI2 is an important component in the kidney injury/repairing process by preventing the over-activation of fibroblasts during the repairing process and protecting the kidney from fibrosis and decline of renal function. Our findings suggest that PGI2/PTGIR is a potential therapeutic target for CKD.