Morphomics-Informed Population Pharmacokinetic and Physiologically-Based Pharmacokinetic Modeling to Optimize Cefazolin Surgical Prophylaxis.

Shuhan LiuAleksas MatvekasTamara NaimiAws GhanemRuiting LiKrishani RajanayakeBrian DerstineBrian RossJune SullivanHyun Gi YunScott RegenbogenJohn ByrnGrace SuStewart WangManjunath Amit P Pai

Published in: Pharmacotherapy (2023)

Kidney function and morphomics were more informative than body weight as covariates of cefazolin target site exposure. Data from more diverse populations, consensus on target cefazolin exposure, and comparative studies are needed before a change in practice can be implemented.

Keyphrases

body weight
healthcare
primary care
electronic health record
clinical practice
quality improvement
case control
deep learning