Inhibition of Amino Acids Influx into Proximal Tubular Cells Improves Lysosome Function in Diabetes.

Yuzuki Kano Satoshi Yamaguchi Koki MiseChieko KawakitaYasuhiro OnishiNaoko KurookaRyosuke SugawaraHaya Hamed Hassan AlbuayjanAtsuko NakatsukaJun EguchiJun Wada

Published in: Kidney360 (2023)

The reduction of amino acids influx into proximal tubular cells inactivated mTOR, activated TFEB, improved lysosome function, and ameliorated vacuolar formation of PTCs in STZ-HFD-Cltrn-/y mice.

Keyphrases

induced apoptosis
amino acid
cell cycle arrest
type diabetes
cardiovascular disease
oxidative stress
cell proliferation
high fat diet
endoplasmic reticulum stress
signaling pathway
cell death
living cells
metabolic syndrome
high glucose
endothelial cells
pi k akt
diabetic rats
weight loss