Phytochemical Composition, Antifungal and Antioxidant Activity of Duguetia furfuracea A. St.-Hill.
Francisca Valéria Soares de Araújo PinhoLitiele Cezar da CruzNathane Rosa RodriguesEmily Pansera WaczukCelestina Elba Sobral SouzaHenrique Doouglas Melo CoutinhoJosé Galberto Martins da CostaMargareth Linde AthaydeAline Augusti BoligonJeferson Luis FrancoThaís PosserIrwin Rose Alencar de MenezesPublished in: Oxidative medicine and cellular longevity (2016)
HPLC analysis revealed caffeic acid and rutin as major compounds (HEDF), caffeic acid and quercitrin (Mt-OH fraction), and quercitrin and isoquercitrin (Ac-OEt fraction). The highest levels of phenols and total flavonoids were found for Ac-OEt fraction, and the crude extract showed higher in vitro antioxidant potential. The antifungal activity showed synergic effect with fluconazole and EHDF against C. krusei, fluconazole and Mt-OH against C. krusei and C. tropicalis, and Ac-OE and fluconazole against C. albicans. Conclusion. The highest levels of phenols and total flavonoids were marked with antioxidant effect. This is the first report of bioactivity of the synergic effect of HEDF and fractions. More studies would be required to better clarify its mechanism of synergic action.