Role of TLR4-p38 MAPK-Hsp27 signal pathway in LPS-induced pulmonary epithelial hyperpermeability.
Weiju WangJie WengLei YuQiaobing HuangYong JiangXiaohua GuoPublished in: BMC pulmonary medicine (2018)
Our study demonstrated that LPS increased alveolar epithelial permeability both in vitro and in vivo and that TLR4- p38 MAPK- Hsp27 signal pathway dependent actin remolding was involved in this process.