Adipose methylome integrative-omic analyses reveal genetic and dietary metabolic health drivers and insulin resistance classifiers.
Colette E ChristiansenMax TomlinsonMelissa EliotEmma NilssonRicardo CosteiraYujing XiaSergio VillicañaOlatz MompeoPhilippa WellsJuan Castillo-FernandezLouis PotierMarie-Claude VohlAndre TchernofJulia El-Sayed MoustafaCristina MenniClaire J StevesKarl KelseyCharlotte LingElin GrundbergKerrin S SmallJordana T BellPublished in: Genome medicine (2022)
Our findings help characterise the adiposity-associated methylation signature of SAT, with insights for metabolic disease risk.
Keyphrases
- insulin resistance
- genome wide
- adipose tissue
- high fat diet
- skeletal muscle
- metabolic syndrome
- healthcare
- type diabetes
- public health
- dna methylation
- polycystic ovary syndrome
- high fat diet induced
- mental health
- single cell
- copy number
- health information
- climate change
- glycemic control
- network analysis
- gene expression