Upregulation of the CD155-CD226 Axis Is Associated With Muscle Inflammation and Disease Severity in Idiopathic Inflammatory Myopathies.

Wenli Li Chuiwen Deng Hanbo Yang Xiaolan Tian Lida Chen Qingyan Liu Chang Gao Xin Lu Guo-Chun Wang Qing-Lin Peng

Published in: Neurology(R) neuroimmunology & neuroinflammation (2023)

These findings demonstrate that the CD155-CD226 axis is highly activated in inflamed muscle tissues of patients with IIM and is associated with muscle disease severity. Our data uncover the immunopathogenic role of the axis in the pathology of IIMs.

Keyphrases

skeletal muscle
oxidative stress
gene expression
cell proliferation
electronic health record
signaling pathway
big data
artificial intelligence
long non coding rna
data analysis