Increased serum calpain activity is associated with HMGB1 levels in systemic sclerosis.

Ji-Na ZhengYang LiYue-Mei YanYong YuWen-Qi ShaoQiang Wang

Published in: Arthritis research & therapy (2020)

This is the first study that reports increased serum calpain activity and the correlation between calpain and HMGB1 in patients with SSc or SSc-ILD. The serum calpain activity and HMGB1 levels may serve as measures of ILD in patients with SSc. Also, calpain and HMGB1 could be potential therapeutic targets for patients with SSc or SSc-ILD in the future.

Keyphrases

interstitial lung disease
systemic sclerosis
rheumatoid arthritis
emergency department
risk assessment
current status