Effect of pomegranate extract on vagina, skeleton, metabolic and endocrine profiles in an ovariectomized rat model.

In rats fed with pomegranate extract, estradiol levels increased and tibial bone cortex thickness and vaginal epithelium thickness also increased. Pomegranate itself or its formulation extracts may be a support or an alternative to the main treatment modalities in the preservation of bone density and the treatment of vaginal epithelial atrophy.