Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer.
Shania M CorryAmy Mb McCorryTamsin Rm LannaganNiamh A LeonardNatalie C FisherRyan M ByrnePetros TsantoulisXabier Cortes-LavaudRaheleh AmirkhahKeara L RedmondAoife J McCooeySudhir B MallaEmily RoganSvetlana SakhnevychMichael A GillespieMark WhiteSusan D RichmanRene-Filip JackstadtAndrew D CampbellSarah Maguirenull nullSimon S McDadeDaniel B LongleyMaurice B LoughreyHelen G ColemanEmma M KerrSabine TejparTimothy MaughanSimon J LeedhamDonna M SmallAideen E RyanOwen J SansomMark LawlerPhilip D DunnePublished in: Gut (2022)
This study reveals new biological insight that offers a novel therapeutic option to reduce relapse rates in patients with the worst prognosis CC.