Novel Respiratory Disability Score Predicts COPD Exacerbations and Mortality in the SPIROMICS Cohort.
Christopher B CooperRobert PaineJeffrey L CurtisRichard E KannerCarlos H MartinezCatherine A MeldrumRussell BowlerWanda O'NealEirc A HoffmanDavid J CouperMiguel QuibreraGerald CrinerMark T DransfieldMeiLan K HanNadia N HanselJerry A KrishnanStephen C LazarusStephen P PetersR Graham BarrFernando J MartinezPrescott G Woodruffnull nullPublished in: International journal of chronic obstructive pulmonary disease (2020)
Our novel SPIROMICS respiratory disability score in COPD was associated with worse airflow obstruction as well as airway wall thickening, lung parenchymal destruction and certain inflammatory biomarkers. The disability score also proved to be an independent predictor of future exacerbations and death. These findings validate disability as an important phenotype in the spectrum of COPD.