Insights into the protective capacity of human dental pulp stem cells and its secretome in cisplatin-induced nephrotoxicity: effects on oxidative stress and histological changes.

Esmail RanjbarJalil Tavakol AfshariAbolfazl KhajaviRadAlireza Ebrahimzadeh-BideskanReihaneh Shafieian

Published in: Journal of basic and clinical physiology and pharmacology (2022)

The current study described the first comparative evidence of reno-protective potential of hDPSCs and their CM against cisplatin-induced nephrotoxicity in an AKI rat model, proposing them as useful adjunctive therapy in AKI. Yet, future explorations are still needed.

Keyphrases

stem cells
acute kidney injury
oxidative stress
endothelial cells
drug induced
dna damage
cell therapy
current status
induced pluripotent stem cells
bone marrow
human health
signaling pathway