Genomic comparison of paired primary breast carcinomas and lymph node macrometastases using the Oncotype DX Breast Recurrence Score® test.

Susan K BoolbolManju HarshanManjeet ChadhaLaurie KirsteinJean-Marc CohenPaula KleinJoseph AndersonDeborah DavisonDebbie M JakubowskiFrederick L BaehnerStephen Malamud

Published in: Breast cancer research and treatment (2019)

There is modest correlation in continuous gene expression, as measured by the RS and single-gene results for ER, PR, and HER2 between paired primary tumors and synchronous nodal metastases. RS testing for ER+ breast cancer should continue to be based on analysis of primary tumors.

Keyphrases

lymph node
gene expression
neoadjuvant chemotherapy
dna methylation
endoplasmic reticulum
high grade
radiation therapy
early stage