Concurrent RB1 loss and BRCA -deficiency predicts enhanced immunological response and long-term survival in tubo-ovarian high-grade serous carcinoma.
Flurina A M SanerKazuaki TakahashiTimothy BuddenAhwan PandeyDinuka AriyaratneTibor A ZwimpferNicola S MeagherSian FeredayLaura TwomeyKathleen I PishasTherese HoangAdelyn BolithonNadia TraficanteKathryn AlsopElizabeth L ChristieEun-Young KangGregg S NelsonPrafull GhatageCheng-Han LeeMarjorie J RigganJennifer AlsopMatthias W BeckmannJessica BorosAlison H BrandAngela Brooks-WilsonMichael E CarneyPenny CoulsonMadeleine Courtney-BrooksKara L Cushing-HaugenCezary CybulskiMona A El-BahrawyEsther ElishaevRamona ErberSimon A GaytherAleksandra Gentry-MaharajC Blake GilksPaul R HarnettHolly R HarrisArndt HartmannAlexander HeinJoy HendleyAocs GroupBrenda Y HernandezAnna JakubowskaMercedes Jimenez-LinanMichael E JonesScott H KaufmannCatherine J KennedyTomasz KluzJennifer M KoziakBjörg KristjansdottirNhu D LeMarcin LenerJenny LesterJan LubińskiConstantina MateoiuSandra OrsulicMatthias RuebnerMinouk J SchoemakerMitul ShahRaghwa SharmaMark E ShermanYurii B ShvetsovNaveena SinghT Rinda SoongHelen SteedPaniti SukumvanichAline TalhoukSarah E TaylorRobert A VierkantChen WangMartin WidschwendterLynne R WilkensStacey J WinhamMichael S AnglesioAndrew BerchuckJames D BrentonIan CampbellLinda S CookJennifer A DohertyPeter A FaschingRenée T FortnerMarc T GoodmanJacek GronwaldDavid G HuntsmanBeth Y KarlanLinda E KelemenUsha MenonFrancesmary ModugnoPaul D P PharoahJoellen M SchildkrautKarin SundfeldtAnthony J SwerdlowEllen L GoodeAnna DeFazioMartin KöbelSusan J RamusDavid D L BowtellDale W GarsedPublished in: medRxiv : the preprint server for health sciences (2023)
mutation was associated with exceptionally long survival in patients with HGSC, potentially due to better treatment response and immune stimulation.