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Is glucagon-like peptide-1 fully protected by the dipeptidyl peptidase 4 inhibitor sitagliptin when administered to patients with type 2 diabetes?

Emilie S AndersenAsger LundJonatan I BaggerCamilla AndreasenMagnus F GrøndahlCarolyn F DeaconBolette HartmannJens J HolstFilip K Krag KnopTina Vilsbøll
Published in: Diabetes, obesity & metabolism (2018)
Our findings suggest that the sitagliptin dose of 100 mg is sufficient to inhibit both plasma and membrane-bound DPP-4 activity, presumably also leading to complete protection of endogenous GLP-1 in patients with T2D.
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