Extremely Rare Pulmonary Metastases of Skin Basal Cell Carcinoma: Report of Two Cases with Clinicopathological Features.
Małgorzata Edyta WojtyśKajetan KiełbowskiMichał KuncSeweryn Adam SkrzyniarzPiotr LisowskiRafał BechtPaulina ŻukowskaKonrad PtaszyńskiJanusz WójcikPublished in: Biomedicines (2023)
Basal cell carcinoma (BCC) is the most frequent human skin cancer, but metastasizing BCC (MBCC) is extremely rare, developing in approximately 0.0028% to 0.55% of BCC patients. Herein, we report two cases of pulmonary MBCC. The first one developed in a 72-year-old male who underwent surgical resection due to multiple recurrences and adjuvant radiotherapy. Immunohistochemistry showed that neoplastic cells expressed Ber-EP4, CK5/6, p63, EMA (focally), BCL-2, and CD10, but were negative for CK7, CK20, S100, estrogen and progesterone receptors, and TTF-1. The second case is a 64-year-old female treated with vismodegib. Clinicopathological features and differential diagnoses are described.
Keyphrases
- basal cell carcinoma
- skin cancer
- end stage renal disease
- protein kinase
- early stage
- pulmonary hypertension
- newly diagnosed
- endothelial cells
- induced apoptosis
- chronic kidney disease
- estrogen receptor
- radiation therapy
- cell cycle arrest
- locally advanced
- oxidative stress
- signaling pathway
- wound healing
- induced pluripotent stem cells