Macrophage roles in the clearance of apoptotic cells and control of inflammation in the prostate gland after castration.

Juliete A F SilvaAlexandre Bruni-CardosoTaize M AugustoDanilo M Damas-SouzaGuilherme O BarbosaSérgio L FelisbinoDagmar R Stach-MachadoHernandes F Carvalho

Published in: The Prostate (2017)

CD68+ macrophages phagocytose apoptotic cell corpses and activate the LAP pathway, thereby contributing to the preservation of a non-inflammed microenvironment. Marked inflammation was detected when autophagy blockers were administered to castrated animals.

Keyphrases

cell death
cell cycle arrest
oxidative stress
induced apoptosis
prostate cancer
endoplasmic reticulum stress
stem cells
cell therapy
signaling pathway
adipose tissue
benign prostatic hyperplasia
cell proliferation
mesenchymal stem cells
bone marrow
nk cells