A single, oral dose of the TLR7 agonist JNJ-64794964 induces transcriptomic and phenotypic changes in peripheral immune cells in healthy adults.

Wim PiersonMarianne TuefferdFlorence HerschkeLeen SlaetsMarjolein CrabbeDorien VerstappenSteffi De PelsmaekerIan StricklandEdward J GaneChristian SchwabeYingjie ZhangPeter MeertsJoris Vandenbossche Pieter Van Remoortere Inge VerbruggeAn De Creus

Published in: Antiviral therapy (2023)

JNJ-4964 administration led to changes in transcriptional profiles and immune cell activation phenotype, particularly for NK cells and B cells. Together, these changes could represent a set of biomarkers for the characterization of the immune response in CHB patients receiving TLR7 agonists.

Keyphrases

immune response
nk cells
toll like receptor
inflammatory response
dendritic cells
gene expression
single cell
transcription factor
rna seq
heat shock
chemotherapy induced
heat shock protein