Kinesin-5 Eg5 is essential for spindle assembly and chromosome alignment of mouse spermatocytes.

Zhen-Yu SheNing ZhongKai-Wei YuYu XiaoYa-Lan WeiYang LinYue-Ling LiMing-Hui Lu

Published in: Cell division (2020)

Our results have revealed an important role of kinesin-5 Eg5 in male meiosis and the maintenance of male fertility. We demonstrate that Eg5 is crucial for bipolar spindle assembly and chromosome alignment in dividing spermatocytes. Our data provide insights into the functions of Eg5 in meiotic spindle assembly of dividing spermatocytes.

Keyphrases

copy number
bipolar disorder
electronic health record
gene expression
big data
machine learning
dna methylation
data analysis