Parkinsonian traits in amyotrophic lateral sclerosis (ALS): a prospective population-based study.

Andrea CalvoAdriano ChiòMarco PaganiStefania CammarosanoFrancesca DematteisCristina MogliaLuca SoleroUmberto ManeraTiziana MartoneMaura BrunettiMichele BalmaGiancarlo CastellanoMarco BarberisAngelina CistaroCarlo Alberto ArtusiRosario VastaElisa MontanaroAlberto RomagnoloBarbara IazzolinoAntonio CanosaGiovanna CarraraConsuelo ValentiniTie-Qiang LiFlavio NobiliLeonardo LopianoMario G Rizzone

Published in: Journal of neurology (2019)

In our study, about 30% of ALS patients showed PK signs. Neuroimaging data indicate that PK signs are due to the involvement of brain circuitries other than classical nigrostriatal ones, strengthening the hypothesis of ALS as a complex multisystem disease.

Keyphrases

amyotrophic lateral sclerosis
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
genome wide
big data
multiple sclerosis
machine learning
dna methylation
patient reported outcomes
brain injury
subarachnoid hemorrhage
functional connectivity