Ibrutinib-associated necrotic nasal lesion and pulmonary infiltrates.
Christopher F SalingFionna FellerHolenarasipur R VikramPublished in: BMJ case reports (2021)
Herein, we report a case of a 68-year-old woman receiving ibrutinib for chronic lymphocytic leukaemia, who presented with septic shock and a progressive necrotic lesion on her nose. Surgical pathology of the nasal lesion revealed evidence of tissue necrosis, and both tissue and blood culture grew Pseudomonas aeruginosa A diagnosis of ecthyma gangrenosum was made. Additional investigations also led to the discovery of invasive pulmonary aspergillosis. To our knowledge, this is the first case of ecthyma gangrenosum secondary to Pseudomonas sepsis and concurrent invasive pulmonary aspergillosis associated with ibrutinib use.
Keyphrases
- septic shock
- pulmonary hypertension
- pseudomonas aeruginosa
- chronic lymphocytic leukemia
- multiple sclerosis
- healthcare
- small molecule
- intensive care unit
- cystic fibrosis
- biofilm formation
- acute kidney injury
- high throughput
- chronic rhinosinusitis
- single cell
- escherichia coli
- squamous cell carcinoma
- acinetobacter baumannii
- staphylococcus aureus
- drug resistant
- plant growth