Inhibition of HDAC and Signal Transduction Pathways Induces Tight Junctions and Promotes Differentiation in p63-Positive Salivary Duct Adenocarcinoma.

Masaya NakanoKizuku OhwadaYuma ShindoTakumi Konno Takayuki KohnoShin KikuchiMitsuhiro TsujiwakiDaichi IshiiSoshi NishidaTakuya KakukiKazufumi ObataRyo MiyataMakoto KuroseAtsushi KondohKenichi TakanoTakashi Kojima

Published in: Cancers (2022)

p63 is not only a diagnostic marker of salivary gland neoplasia, but it also promotes the malignancy. Inhibition of HDAC and signal transduction pathways is, therefore, useful in therapy for p63-positive SDC cells.

Keyphrases

induced apoptosis
histone deacetylase
cell cycle arrest
squamous cell carcinoma
blood brain barrier
high grade
cell death
rectal cancer