Insulin-like growth factor binding protein-2: a new circulating indicator of pulmonary arterial hypertension severity and survival.
Jun YangMegan GriffithsMelanie K NiesStephanie BrandalRachel DamicoDhananjay VaidyaXueting TaoCatherine E SimpsonTodd M KolbStephen C MathaiMichael W PauciuloWilliam C NicholsDavid D IvyEric D AustinPaul M HassounAllen D EverettPublished in: BMC medicine (2020)
IGFBP2 protein expression was increased in the PAH lung, and secreted by PASMC. Elevated circulating IGFBP2 was associated with PAH severity and mortality and is a potentially valuable prognostic marker in PAH.