Combined Inhibition of G9a and EZH2 Suppresses Tumor Growth via Synergistic Induction of IL24-Mediated Apoptosis.
Francesco CascielloGregory M KellyPriya Ramarao-MilneNabilah KamalTeneale A StewartPamela MukhopadhyayStephen H KazakoffMariska MirandaDorim KimFelicity Mae DavisNicholas K HaywardPaula M VertinoNicola WaddellFrank GannonJason S LeePublished in: Cancer research (2022)
These findings demonstrate a novel role for G9a and EZH2 histone methyltransferases in suppressing apoptosis, which can be targeted with small molecule inhibitors as a potential approach to improve solid cancer treatment.