Abrus precatorius Leaf Extract Reverses Alloxan/Nicotinamide-Induced Diabetes Mellitus in Rats through Hormonal (Insulin, GLP-1, and Glucagon) and Enzymatic (α-Amylase/α-Glucosidase) Modulation.
Alex BoyeVictor Yao Atsu BarkuDesmond Omane AcheampongEric Gyamerah OforiPublished in: BioMed research international (2021)
Antidiabetic effect of APLE is mediated through modulation of insulin and GLP-1 inversely with glucagon, noncompetitive inhibition of α-amylase and α-glucosidase, free radical scavenging, and recovery of damaged/necro-apoptosized pancreatic β-cells.
Keyphrases
- type diabetes
- glycemic control
- molecular docking
- induced apoptosis
- cell cycle arrest
- high glucose
- diabetic rats
- hydrogen peroxide
- oxidative stress
- polycystic ovary syndrome
- metabolic syndrome
- nitric oxide
- signaling pathway
- endothelial cells
- insulin resistance
- pi k akt
- molecular dynamics simulations
- cell proliferation