Comparative risk of gout flares when initiating or escalating various urate-lowering therapy: a systematic review with network meta-analysis.

Dorsa MaherEmily ReeveAshley HopkinsJiun Ming TanMahsa TantiongcoNagham AilabouniRichard WoodmanLisa K StampDavid BursillSusanna ProudmanMichael D Wiese

Published in: Arthritis care & research (2024)

The relative risk of flares when introducing ULT varies depending on ULT drug and dosing strategy. There was limited data on ULT escalation. Flare prophylaxis with colchicine and rilonacept reduces flare incidence. More research is required on the harms and optimal duration of prophylaxis.

Keyphrases

systematic review
meta analyses
risk factors
electronic health record
uric acid
open label
clinical trial
case control
mesenchymal stem cells
deep learning