Umbelliferone Inhibits Spermatogenic Defects and Testicular Injury in Lead-Intoxicated Rats by Suppressing Oxidative Stress and Inflammation, and Improving Nrf2/HO-1 Signaling.
Mohammed F AlotaibiFakhria Al-JoufiHowida S Abou SeifMohammed A AlzoghaibiLaiche DjouhriAhmad F AhmedaAyman Moawad MahmoudPublished in: Drug design, development and therapy (2020)
UMB prevents Pb-induced testicular injury by suppressing oxidative damage, inflammation and cell death, and boosting antioxidant defenses, Nrf2/HO-1 signaling and pituitary-gonadal axis. Thus, UMB may represent a protective and cost-effective agent against Pb testicular toxicity, pending further investigations to elucidate other underlying mechanisms.