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cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets.

Stephanie MakhoulKatharina TraboldStepan GambaryanStefan TenzerDaniele PillitteriUlrich WalterKerstin Jurk
Published in: Cell communication and signaling : CCS (2019)
EB and EM are specific agonists and antagonists, respectively, of GPIbα-mediated Syk activation leading to platelet aggregation. The cAMP/PKA and cGMP/PKG pathways do not inhibit but enhance GPIbα-/GPVI-initiated, SFK-dependent Syk activation, but strongly inhibit further downstream responses including aggregation. These data establish an important intracellular regulatory network induced by GPIbα.
Keyphrases
  • tyrosine kinase
  • protein kinase
  • nitric oxide
  • endothelial cells
  • binding protein
  • electronic health record
  • big data
  • reactive oxygen species