cAMP- and cGMP-elevating agents inhibit GPIbα-mediated aggregation but not GPIbα-stimulated Syk activation in human platelets.

Stephanie MakhoulKatharina TraboldStepan GambaryanStefan TenzerDaniele PillitteriUlrich WalterKerstin Jurk

Published in: Cell communication and signaling : CCS (2019)

EB and EM are specific agonists and antagonists, respectively, of GPIbα-mediated Syk activation leading to platelet aggregation. The cAMP/PKA and cGMP/PKG pathways do not inhibit but enhance GPIbα-/GPVI-initiated, SFK-dependent Syk activation, but strongly inhibit further downstream responses including aggregation. These data establish an important intracellular regulatory network induced by GPIbα.

Keyphrases

tyrosine kinase
protein kinase
nitric oxide
endothelial cells
binding protein
electronic health record
big data
reactive oxygen species