LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover.
Yuki TanakaYuta ShimanakaAndrea CaddeoTakuya KuboYanli MaoTetsuya KubotaNaoto KubotaToshimasa YamauchiRosellina Margherita MancinaGuido BaselliPanu LuukkonenJussi PihlajamäkiHannele Yki-JärvinenLuca Vittorio ValentiHiroyuki AraiStefano RomeoNozomu KonoPublished in: Gut (2020)
We found a novel pathway fueling triglyceride synthesis in hepatocytes, by a direct metabolic flow of PI into triglycerides. Our findings provide an insight into the pathogenesis and therapeutics of NAFLD.