Platelet inhibition by P2Y12 antagonists is potentiated by adenosine signalling activators.
Chih-Chin ShihMelissa Victoria ChanNicholas S KirkbyIvana VojnovicJane A MitchellPaul C J ArmstrongTimothy David WarnerPublished in: British journal of pharmacology (2021)
These results indicate that P2Y12 antagonists have a synergistic relationship with adenosine signalling and that their efficacy may depend partly upon the presence of endogenous adenosine. This effect was common for prasugrel and ticagrelor despite reports of differences in their effects upon adenosine reuptake.