Genomic and transcriptomic analysis of a diffuse pleural mesothelioma patient-derived xenograft library.

Michael OffinJennifer L SauterSam E TischfieldJacklynn V EggerShweta ChavanNisargbhai S ShahParvathy ManojKatia VenturaViola AllajElisa de StanchinaWilliam TravisMarc LadanyiAndreas RimnerValerie W RuschPrasad S AdusumilliJohn T PoirierMarjorie G ZaudererCharles M RudinTriparna Sen

Published in: Genome medicine (2022)

These data demonstrate that DPM PDX models closely resemble the genotype and phenotype of parental tumors, and identify pathways altered in DPM for future exploration in preclinical studies.

Keyphrases

electronic health record
current status
low grade
case control
big data
copy number
cell therapy
stem cells
gene expression
machine learning
mesenchymal stem cells
dna methylation
bone marrow
artificial intelligence
deep learning