Release of Amino- or Carboxy-Containing Compounds Triggered by HOCl: Application for Imaging and Drug Design.
Peng WeiLingyan LiuYing WenGuilong ZhaoFengfeng XueWei YuanRuohan LiYaping ZhongMengfan ZhangTao YiPublished in: Angewandte Chemie (International ed. in English) (2019)
The overproduction of HOCl is highly correlated with diseases such as atherosclerosis, rheumatoid arthritis, and cancer. Whilst acting as a marker of these diseases, HOCl might also be used as an activator of prodrugs or drug delivery systems for the treatment of the corresponding disease. In this work, a new platform of HOCl probes has been developed that integrates detection, imaging, and therapeutic functions. The probes can detect HOCl, using both NIR emission and the naked eye in vitro, with high sensitivity and selectivity at ultralow concentrations (the detection limit is at the nanomolar level). Basal levels of HOCl can be imaged in HL-60 cells without special stimulation. Moreover, the probes provided by this platform can rapidly release either amino- or carboxy-containing compounds from prodrugs, during HOCl detection and imaging, to realize a therapeutic effect.
Keyphrases
- fluorescence imaging
- high resolution
- rheumatoid arthritis
- small molecule
- loop mediated isothermal amplification
- living cells
- real time pcr
- label free
- induced apoptosis
- high throughput
- single molecule
- cardiovascular disease
- fluorescent probe
- squamous cell carcinoma
- cell cycle arrest
- mass spectrometry
- systemic sclerosis
- type diabetes
- nuclear factor
- signaling pathway
- idiopathic pulmonary fibrosis
- electronic health record
- endoplasmic reticulum stress
- drug release