Direct oral anticoagulants in patients with nonvalvular atrial fibrillation and extreme body weight.
Francesca BodegaAnita RussiFrancesco MelilloFabiana BlundaClaudia RubinoGiulio LeoAlberto CappellettiPatrizio MazzonePaolo MattielloPaolo Della BellaAlessandro CastiglioniOttavio AlfieriMichele De BonisMatteo MontorfanoMoreno TresoldiMassimo FilippiAnna SalernoMichela CeraAlberto ZangrilloMargonato AlbertoCosmo Godinonull nullPublished in: European journal of clinical investigation (2021)
In this tertiary care centre registry, 15% of patients treated with DOACs presented an extreme weight. Compared to patients with a normal weight, no significant rates of thromboembolic events were observed for underweight or overweight patients. A trend towards decreased overall bleeding frequency as weight increased was highlighted up to 2 years. The present results should be considered as preliminary and hypothesis generating.
Keyphrases
- direct oral anticoagulants
- atrial fibrillation
- body weight
- venous thromboembolism
- weight loss
- weight gain
- physical activity
- oral anticoagulants
- body mass index
- left atrial
- catheter ablation
- tertiary care
- left atrial appendage
- end stage renal disease
- newly diagnosed
- ejection fraction
- heart failure
- climate change
- percutaneous coronary intervention
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- coronary artery disease
- patient reported
- acute coronary syndrome