Lung function in school-aged congenital diaphragmatic hernia patients; a longitudinal evaluation.
Leontien C C Toussaint-DuysterMonique H M van der Cammen-van ZijpMarjolein SpoelHarm A W M TiddensDick TibboelRene M H WijnenJoost van RosmalenHanneke IJsselstijnPublished in: Pediatric pulmonology (2019)
Seventy-six children (27 ECMO-treated) born between 1999 and 2009 performed 113 reliable lung function tests. Severity of airflow obstruction deteriorated significantly from age 8 to 12 years: estimated mean difference (95% confidence interval [CI]) SDS FEV1 was -0.57 (-0.79 to -0.36) and SDS FEF25-75 was -0.63 (-0.89 to -0.37), both P < .001. Static lung volumes were within normal range and unchanged over time: estimated mean difference (95% CI) SDS TLC -0.27 (-0.58 to 0.04); P = .085. SDS KCO was below normal at 8 and 12 years and remained stable: -0.06 (-0.22 to 0.35); P = .648. These observations were irrespective of ECMO treatment. FEV1 and FEF25-75 were negatively associated with duration of ventilation (P < .001). Baseline data were not related with TLC or KCO. CONCLUSIONS: CDH patients should be followed into adulthood as they are at risk for worsening airflow obstruction and decreased diffusion capacity at school age, irrespective of ECMO treatment.
Keyphrases
- lung function
- end stage renal disease
- extracorporeal membrane oxygenation
- newly diagnosed
- cystic fibrosis
- chronic obstructive pulmonary disease
- acute respiratory distress syndrome
- chronic kidney disease
- air pollution
- peritoneal dialysis
- physical activity
- respiratory failure
- mental health
- intensive care unit
- combination therapy
- preterm infants
- deep learning
- low birth weight
- patient reported
- smoking cessation
- data analysis