Detection of axonal degeneration in a mouse model of Huntington's disease: comparison between diffusion tensor imaging and anomalous diffusion metrics.
Richard L MaginAllen Q YeLuis Colon-PerezThomas H MareciAnna LysakowskiSteven D PriceScott T BradyMuge KaramanGerardo MorfiniRichard L MaginPublished in: Magma (New York, N.Y.) (2019)
DTI and CTRW diffusion models display quantitative changes associated with the microstructural alterations observed in the corpus callosum of the R6/2 mice. The observed increase in the diffusivity and decrease in the alpha CTRW parameter providing support for the use of these diffusion models for non-invasive detection of white matter alterations in HD.