Role of ADAMTS13, VWF and F8 genes in deep vein thrombosis.

Maria Teresa PagliariAndrea CairoMarco BoscarinoIlaria ManciniEmanuela PappalardoPaolo BucciarelliIda MartinelliFrits R RosendaalFlora Peyvandi

Published in: PloS one (2021)

ADAMTS13 and VWF low-frequency/common variants mainly showed a protective effect, although their association with DVT was not confirmed. DVT patients carrying a rare ADAMTS13 variants had slightly reduced ADAMTS13 activity levels, but a higher DVT risk. Rare VWF and FVIII variants were not associated with DVT suggesting that other mechanisms are responsible for the high VWF and FVIII levels measured in DVT patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
copy number
peritoneal dialysis
gene expression
patient reported outcomes