Melatonin salvages lead-induced neuro-cognitive shutdown, anxiety, and depressive-like symptoms via oxido-inflammatory and cholinergic mechanisms.

Noah A OmeizaHalimat A AbdulrahimIsiaka Abdullateef AlagbonsiPrecious U EzurikeTalha K SoluokuHappy IsiaborAbdulmusawwir A Alli-Oluwafuyi

Published in: Brain and behavior (2021)

These findings suggest that melatonin down-regulates neurotoxicant interplays in the brain systems. Therefore, this study suggests the use of melatonin as an adjuvant therapy in neuropathological disorders/dysfunctions.

Keyphrases

sleep quality
high glucose
diabetic rats
resting state
endothelial cells
drug induced
physical activity
brain injury
blood brain barrier