Ring1b-dependent epigenetic remodelling is an essential prerequisite for pancreatic carcinogenesis.

Simone BenitzTobias StraubUjjwal Mukund MahajanJurik MutterStefan CzemmelTatjana UnruhBritta WingerathSabrina DeublerLisa FahrTao ChengSven NahnsenPhilipp BrunsBo KongSusanne RaulefsGüralp O CeyhanJulia MayerleKatja SteigerIrene EspositoJörg KleeffChristoph W MichalskiIvonne Regel

Published in: Gut (2019)

Our data provide substantial evidence that the epigenetic silencing of acinar cell fate genes is a mandatory event in the development and progression of pancreatic cancer. Targeting the epigenetic repressor Ring1b could offer new therapeutic options.

Keyphrases

dna methylation
cell fate
gene expression
genome wide
cancer therapy
transcription factor
data analysis