Deciphering the Divergent Gene Expression Landscapes of m6A/m5C/m1A Methylation Regulators in Hepatocellular Carcinoma Through Single-Cell and Bulk RNA Transcriptomic Analysis.

Hang-Tsung LiuCheng-Shyuan RauYueh-Wei LiuTing-Min HsiehChun-Ying HuangPeng-Chen ChienHui-Ping LinChia-Jung WuPei-Chin ChuangChing-Hua Hsieh

Published in: Journal of hepatocellular carcinoma (2023)

This study suggests that cellular diversity inside tumors contributes to the discrepancy in the expression of methylation regulator genes between traditional bulk sequencing and scRNA-seq. This study identified five regulatory genes that will be the focus of further studies regarding the function of m6A/m5C/m1A in HCC.

Keyphrases

single cell
genome wide
gene expression
dna methylation
transcription factor
rna seq
high throughput