Development and validation of novel sepsis subphenotypes using trajectories of vital signs.
Sivasubramanium V BhavaniMatthew SemlerEdward T QianPhilip A VerhoefChad RobichauxMatthew M ChurpekCraig M CoopersmithPublished in: Intensive care medicine (2022)
Sepsis sub-phenotypes based on vital sign trajectory were consistent across cohorts, had distinct outcomes, and different responses to treatment with balanced crystalloids versus saline.