Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation.
Yuan YuanHuizhong LiKashyap SreeramTuyana MalankhanovaRavindra BodduSamuel StraderAllison ChangNicole BryantTalene A YacoubianDavid G StandaertMadalynn ErbDarren J MooreLaurie H SandersMichael W LutzDmitry VelmeshevAndrew B WestPublished in: bioRxiv : the preprint server for biology (2024)
The extracellular ratio of pT73-Rab10 to total Rab10 in serum is a novel pharmacodynamic biomarker for LRRK2-linked innate immune activation associated with disease severity in iPD. We propose that those iPD patients with higher serum pT73-Rab10 levels may benefit from LRRK2-targeting therapeutics to mitigate associated deleterious immunological responses.