Circulating Extracellular Vesicle-Propagated microRNA Signature as a Vascular Calcification Factor in Chronic Kidney Disease.
Takaaki KoideShintaro MandaiReo KitaokaHisazumi MatsukiMotoko ChigaKouhei YamamotoTakanori YokotaYohsuke YagiSoichiro SuzukiTamami FujikiFumiaki AndoTakayasu MoriKoichiro SusaSoichiro IimoriShotaro NaitoEisei SoharaTatemitsu RaiTakanori YokotaShinichi UchidaPublished in: Circulation research (2023)
The miRNA transcriptomic signature of circulating sEVs uncovered their pathologic role, devoid of the calcification-protective miRNAs that target VEGFA signaling in CKD-driven vascular calcification. These sEV-propagated miRNAs are potential biomarkers and therapeutic targets for vascular calcification.