Evaluating the thrombin generation profiles of four different rFVIII products in FVIII-deficient plasma using FIXa and FXIa activation.
Donald F BrophyErika G MartinMarisa NinivaggiBassem M MohammedJohn C BarrettJanice KuhnMelinda E NolteEmily K WatersMirella EzbanPublished in: Haemophilia : the official journal of the World Federation of Hemophilia (2018)
Both FIXa- and FXIa activation results in similar TGA profiles across a FVIII range of 0.1%-33%; however, FIXa activation was more robust at the lowest levels of FVIII compared with FXIa activation.
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