Determination of Highly Polar and Ionic Pesticides in Grape and Pomegranate Using Liquid Chromatography Tandem Mass Spectrometry.

A high-throughput residue analysis method targeting nine polar and ionic compounds in grape and pomegranate involved a single multiresidue extraction, followed by direct analysis using LC-MS/MS. A satisfactory method performance was achieved through intra- and inter-laboratory validation. The method sensitivity met the EU-MRLs and the SANTE/12682/2019 analytical quality control criteria.