Recent Advances with KDM4 Inhibitors and Potential Applications.
Qiong WuBrandon M YoungYan WangAndrew M DavidoffZoran RankovicJun J YangPublished in: Journal of medicinal chemistry (2022)
The histone lysine demethylase 4 (KDM4) family plays an important role in regulating gene transcription, DNA repair, and metabolism. The dysregulation of KDM4 functions is associated with many human disorders, including cancer, obesity, and cardiovascular diseases. Selective and potent KDM4 inhibitors may help not only to understand the role of KDM4 in these disorders but also to provide potential therapeutic opportunities. Here, we provide an overview of the field and discuss current status, challenges, and opportunities lying ahead in the development of KDM4-based anticancer therapeutics.
Keyphrases
- dna repair
- cardiovascular disease
- current status
- dna damage
- type diabetes
- endothelial cells
- metabolic syndrome
- dna methylation
- insulin resistance
- small molecule
- transcription factor
- weight loss
- papillary thyroid
- risk assessment
- skeletal muscle
- genome wide
- adipose tissue
- coronary artery disease
- dna damage response
- gene expression
- weight gain
- genome wide identification
- cardiovascular events