TBX5 R264K acts as a modifier to develop dilated cardiomyopathy in mice independently of T-box pathway.

Nariaki Miyao Yukiko HataHironori IzumiRyo NagaokaYuko OkuIchiro TakasakiTaisuke IshikawaShinya TakaradaMako OkabeHideyuki NakaokaKeijiro IbukiSayaka OzawaTomoyuki YoshidaHideyuki HasegawaNaomasa MakitaNaoki NishidaHisashi MoriFukiko IchidaKeiichi Hirono

Published in: PloS one (2020)

Mice homozygous for Tbx5 R264K showed compensated dilated cardiomyopathy. Thus, TBX5 R264K may have a significant pathogenic role in some cardiomyopathy patients independently of T-box domain pathway.

Keyphrases

end stage renal disease
transcription factor
ejection fraction
high fat diet induced
newly diagnosed
heart failure
prognostic factors
type diabetes
metabolic syndrome
patient reported