Chemotherapy negatively impacts the tumor immune microenvironment in NSCLC: an analysis of pre- and post-treatment biopsies in the multi-center SAKK19/09 study.

Michael A AmreinE D BührerM L AmreinQ LiS RothschildC RietherR JaggiS Savic-PrinceL BubendorfO GautschiA F Ochsenbein

Published in: Cancer immunology, immunotherapy : CII (2020)

Our results suggest that conventional platinum-based chemotherapy negatively impacts the immune microenvironment at the time point of secondary progression.

Keyphrases

stem cells
locally advanced
small cell lung cancer
squamous cell carcinoma
advanced non small cell lung cancer
radiation therapy
combination therapy
brain metastases
smoking cessation