To summarize, our results indicated that KGF-2 reduces the severity of mouse skin photodamage caused by UVB rays by attenuating DNA damage and the inflammatory response, besides inhibiting the mitochondria-mediated intrinsic apoptosis pathway.
Keyphrases
- dna damage
- inflammatory response
- oxidative stress
- lipopolysaccharide induced
- dna repair
- lps induced
- soft tissue
- toll like receptor
- cell death
- wound healing
- endoplasmic reticulum stress
- signaling pathway
- cell cycle arrest
- high fat diet induced
- mouse model
- adipose tissue
- endoplasmic reticulum
- type diabetes
- insulin resistance
- wild type
- pi k akt