Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent.
Lutfun NaharAfaf Al-GroshiAnil KumarSatyajit Dey SarkerPublished in: Molecules (Basel, Switzerland) (2022)
Arbutin, a hydroquinone glucoside, has been detected in ca. 50 plant families, especially in the plants of the Asteraceae, Ericaceae, Proteaceae and Rosaceae families. It is one of the most widely used natural skin-whitening agents. In addition to its skin whitening property, arbutin possesses other therapeutically relevant biological properties, e.g., antioxidant, antimicrobial and anti-inflammatory, as well as anticancer potential. This review presents, for the first time, a comprehensive overview of the distribution of arbutin in the plant kingdom and critically appraises its therapeutic potential as an anticancer agent based on the literature published until the end of August 2022, accessed via several databases, e.g., Web of Science, Science Direct, Dictionary of Natural Products, PubMed and Google Scholar. The keywords used in the search were arbutin, cancer, anticancer, distribution and hydroquinone. Published outputs suggest that arbutin has potential anticancer properties against bladder, bone, brain, breast, cervix, colon, liver, prostate and skin cancers and a low level of acute or chronic toxicity.
Keyphrases
- soft tissue
- anti inflammatory
- public health
- prostate cancer
- oxidative stress
- systematic review
- wound healing
- risk assessment
- spinal cord injury
- liver failure
- resting state
- intensive care unit
- young adults
- multiple sclerosis
- squamous cell carcinoma
- meta analyses
- respiratory failure
- functional connectivity
- cerebral ischemia
- body composition
- postmenopausal women