The Use of Midodrine as an Adjunctive Therapy to Liberate Patients from Intravenous Vasopressors: A Systematic Review and Meta-analysis of Randomized Controlled Studies.
Mohamed HamedSheref A ElseidyAhmed ElkheshenJamal MaherAdel ElmoghrabiAhmed ZaghloulAndrew PanakosSidakpal PanaichMarwan SaadAyman ElbadawiPublished in: Cardiology and therapy (2023)
Among patients with vasopressor-dependent shock, midodrine was not associated with early liberation of vasopressor support or shorter ICU or hospital length of stay. Adding midodrine increased the risk of bradycardia. Further large RCTs are needed to better evaluate the efficacy and safety of midodrine in liberating patients from IV vasopressors.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- healthcare
- peritoneal dialysis
- intensive care unit
- high dose
- low dose
- open label
- patient reported outcomes
- mesenchymal stem cells
- mechanical ventilation
- study protocol
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome